Newborn bloodspot screening of Biliary Atresia Kit

Biliary Atresia

A destructive inflammatory cholangiopathy where intrahepatic and extrahepatic bile ducts are destroyed at varying lengths during the neonatal period.

Background

• Incidence: 1/5000-8,000 live births in China 
• Presents shortly after birth with persistent jaundice, pale stools, and dark urine
• 90% of untreated patients die by 2 years of age (average age of death: 19 months; death due to cirrhosis and liver end-stage liver disease)
• The most common indication for pediatric liver transplantation
• No diagnosis marker for Biliary atresia is available now
• Screening measures ungently needed for early detection and treatment( early Diagnosis and in time Kasai operation greatly improve the outcome; by intervening early, we can prevent liver transplant)